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KMID : 0377619730240050481
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Korean Jungang Medical Journal
1973 Volume.24 No. 5 p.481 ~ p.489
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Effects of Imipramine to the Fetus and the Pregnant Rats
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李洸鎬/Lee, Kwang Ho
白相豪/張家鏞/金炳曄/Baik, Sang Ho/Chang, Ka Yong/Kim, Byung Yeop
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Abstract
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Sprague Dawley strain rats were treated by imipramine once with the doses of 8.3mg on the 6th, 7th, 8th, 9th and 11th, and twice with the same doses on the 6th and 7th, 8th and 9th, l0th and 11th, 11th and 12th, 8th and 10th, 10th and 12th day of gestation.
Gross anomalies in the fetuses were observed and weight, length, and breadth of the brain of the live fetuses, survival rate of fetuses, changes of fetal body weight, and numbers of corpus luteum of maternal ovaries were studied after hysterectomy on the 22nd day of gestation and the following results were obtained.
1. Significant decrease on the weight of the fetal brain occurred in the treated groups, but no significant differences appeared between two groups which were treated once or twice with the injection.
2. Obvious shortening of the length of fetal brain took place in both groups treated with imipramine.
3. As have been observed in the length and weight, shortening of the breadth of the fetal brain occurred in both groups treated respectively.
4. Obvious decrease of the survival. rate was observed in the group treated twice with imipramine, but the earlier injection they received, the more decrease of the effect on survival rate resulted in the groups treated with single injection.
5. Significant changes of the fetal body weight came out in the result of the both group treated with early injection.
6. Numbers of the corpus luteum were not affected by the injection of imipramine.
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